Using data from the Food and Drug Administration for 2004 through 2015, Health
Grove looked at the 150 drugs that are involved in the
highest number of adverse reactions and ranked them by the percent of these
reactions classified as serious. For many of these reactions, the FDA database
uses medical terminology, such as pyrexia and dyspnoea for fever and labored
breathing, respectively.
The top 50 drugs with the most serious adverse
reactions are considered the most dangerous. Though most on the list require a
prescription and treat serious diseases, those like Advil and acetaminophen don’t.
It’s important to note that these medicines may not be
inherently dangerous, but improper dosage, combining medicines or taking them
with substances like alcohol can dramatically increase risk.
One-third of Americans say they “combine medications when treating multiple symptoms,” according to
the National Council on Patient Information, cited
in a New
York Times report on over-the-counter medicines. The
same source also claims that only one in ten people read the labels entirely
and one in five admits to using medication more than the label indicates. This
creates an environment primed for unintended drug interactions and overdoses.
Additionally, people over 65 years old — those most
likely to take multiple drugs for chronic health issues — account for
approximately 40 percent of over-the-counter drug usage. This puts this group
at greater risk for trouble with these drugs by way of adverse side effects and
interactions.
Despite the potential for negative consequences of drug
use and misuse, modern pharmaceuticals have greatly contributed to the health
and longevity of people around the world. Though many are regarded as safe, as
more drugs become available over the counter and prescriptions of
others rise, consumer awareness becomes increasingly important.
Note: In the case of ties, the drug with the highest
number of total reported reactions is ranked higher.
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